Company History
| October 5, 1989 | Established Mic Co., Ltd. (now Next21 K.K.) with a capital of 10 million yen. |
| 2000 | Signed a joint development agreement with Terumo Corporation for interventional medical devices developed in-house. |
| 2000 | Changed the company name to Next K.K. and increased capital to 25 million yen. |
| August 2001 | Filed a patent application for Dadd, a bio-polymer microparticle with hemostatic and anti-adhesive properties. |
| February 2002 | Filed a patent application for a drug delivery method (Dadd). |
| December 2002 | Filed a patent application for a method of forming artificial bone (CT-Bone). |
| February 2003 | Filed a patent application for a closed-cell culture system. |
| July 2003 | Jointly filed a patent application with RIKEN for a method of forming artificial bone (CT-Bone) using a powder lamination technique. |
| November 2003 | Increased capital to 66.5 million yen. |
| March 2004 | Received a grant from the UFJ New Frontier Enterprise Development Fund for the custom-made transplantable artificial bone "CT-Bone" and full-scale bone model fabrication service. |
| July 2004 | Increased capital to 131,516,000 yen through a third-party allotment to two venture capital firms and Mitsubishi Corporation. |
| October 2004 | Received a grant from the New Energy and Industrial Technology Development Organization (NEDO) for the custom-made artificial bone "CT-Bone." |
| December 2004 | Established the Research Society for 3D Organ Fabrication for Clinical Applications in collaboration with the University of Tokyo TE Department. |
| January 2005 | Filed a patent application for a bone regeneration system (CT-Bone). |
| September 2005 | Increased capital to 157,816,000 yen through a third-party allotment. |
| January 2006 | Filed a patent application for a medical gel-forming composition and its delivery device (gel cartilage). |
| January 2006 | Received approval from the University of Tokyo Hospital IRB (Institutional Review Board) and initiated clinical research on CT-Bone. |
| February 2006 | Filed a patent application for a method of manufacturing bone filler, the bone filler itself, a 3D cell culture scaffold, and a chromatography separation medium (Tetra-Bone). |
| March 2006 | Increased capital to 401,566,000 yen through a third-party allotment. |
| April 2006 | Filed a patent application for an image-forming composition (surgical 3D model). |
| May 2006 | Obtained a patent for Dadd, a bio-polymer microparticle with hemostatic and anti-adhesive properties. (Patent No. 3805654) |
| May 2006 | Received a grant from NEDO for Tetra-Bone. |
| August 2006 | Filed a patent application for bone models and bone fillers (CT-Bone). |
| August 2006 | Filed a patent application for a trehalose-containing oral mucosa protective agent. |
| September 2006 | Received a grant from the National Institute of Biomedical Innovation (NIBIO) for clinical trials of custom-made artificial bone. |
| October 2006 | Received a grant from the Kinki Bureau of Economy, Trade and Industry for the development of advanced manufacturing technology to apply metal laser sintering hybrid processing to medical device products. |
| October 2006 | Received a grant from the National Institute of Biomedical Innovation for clinical trials of transplantable custom-made artificial bone using inkjet powder lamination molding. |
| November 2006 | Filed a patent application for bone filler materials and controlled-release carriers. |
| November 2006 | The joint development project with the University of Tokyo, “Cartilage Regeneration DDS,” was selected by the National Institute of Biomedical Innovation for the FY2006 Basic Research Promotion Program in the field of healthcare and medical science. |
| December 2006 | Made Celex Co., Ltd. a subsidiary through capital integration. Increased capital to 424,566,000 yen. |
| February 2007 | Filed a patent application for a therapeutic or preventive agent for vasospasm. |
| June 2007 | Changed the company name from "Next K.K." to "NEXT21 K.K." . |
| August 2007 | Filed a patent application for a manufacturing method of bone models and bone fillers. |
| August 2007 | Filed a patent application for a trehalose-containing oral mucosa protectant. |
| November 2007 | Filed a patent application for bone fillers, controlled-release carriers, and their manufacturing methods. |
| January 2008 | Obtained a patent for the "closed-cell culture system." |
| February 2008 | Increased capital to 574,566,000 yen through a third-party allotment. |
| April 2008 | Filed a patent application for a 3D surgical guide. |
| June 2008 | Filed a patent application for a bone filler that adsorbs bone growth factors without inhibiting their activity. |
| July 2008 | Filed a patent application for an artificial bone material with controlled calcium ion elution. |
| September 2008 | Selected for the Next-Generation Strategic Core Technology Advancement Program by the New Energy and Industrial Technology Development Organization (NEDO). |
| September 2008 | Filed a patent application for a cartilage defect repair sheet. |
| November 2008 | Two projects involving our company were selected for the Advanced Medical Development Special Zone (Super Special Zone). |
| December 2008 | Filed a patent application for a composition to alleviate NSAIDs-induced gastric mucosal injury. |
| December 2008 | Filed a patent application for an ultra-high strength injectable hydrogel and its manufacturing method. |
| March 2009 | Our research project was selected for the “Pharmaceutical and Medical Device Commercialization Research Support Program (Commissioned Project)” by the National Institute of Biomedical Innovation. |